Let's face it, people don't visit a website to click on ads. They want good content.
If you make the ads stand out with vibrant & mistmatch colors, it makes them stand out as ads. If this is the case people will do whatever they can to avoid them. The same applies to ads that are positioned at the very bottom or tucked away in a corner somewhere. So easy to ignore! If your goal is to generate more clicks, make the ads look an integral part of your content.